701 Materials - Unit wise

 CHN 701(O) Unit-1 Carbohydrates & Purine

1. Which component is found in both guanosine and uridine?

A. Both contain three hydroxyl groups

B. Both contain a pyranose

C. Both contain an aldohexose

D. Both contain a 1-9 - bond.

2. Select the odd one from the following

A. Arabinose

B. xylose

C. lyxose

D. erythrose

3. Which of the following is an aldotriose?

A. Glyceraldehyde

B. Ribulose

C. Dihydroxyacetone

D. Erythrose

4. Identify the purine base of nucleic acids in the following.

A. Cytosine

B. Thymine

C. Adenine

D. Uracil

5. An aldohexose will have stereoisomers

A. 4

B. 16

C. 2

D. 8

6. A major component of RNA but not of DNA is:

A. adenine

B. cytosine

 C. uracil

D. guanine

7. Which structural feature is shared by both uracil and thymine?

A. Both contain a five-membered ring

B. Both contain three nitrogen atoms

C. Both contain two keto groups

D. Both contain one methyl group

8. What is the composition of nucleoside?

A. a base + a sugar

B. a sugar + a phosphate

C. a base + a phosphate

D. a base + a sugar + phosphate

9. Arrangement of nucleotides in DNA can be seen by

A. Electron microscope

B. X -Ray crystallography

C. Light microscope

D. Ultra centrifuge

10. What is the molecular formula of sucrose?

A.  C₁₂H₂₀O₁₁

B.  C ₁₂H₂₂O₁₁

C.  C₁₀H₂₀O₁₀

D. C₆H₁₂O₆

11. Which of the following is not a disaccharide?

A. amylose

B. lactose

C. cellobiose

D. none of these

12. Which property is found in nucleosides and nucleotides?

A. Both contain an aldose with hydroxyl groups that can tautomerize

 B. Both contain a nitrogenous base, a pentose, and at least one phosphate group

C. B oth contain an anomeric carbon atom that is part of a β-N-glycosidic bond

D. Both contain a covalent phosphodister bond that is broken in strong acid

13. Hydrolysis  of lactose yields

A. glucose  and fructose

B. g alactose and glucose

C. fructose  and galactose

D. galactose  and fructose

14. Which of the following is a keto tetrose?

A. Sorbose

B. Xylulose

C. Erythrolose

D. Psicose

15. The glycosidic linkage between two glucose molecules in isomaltose is

A. β 1 – 4

B.    α 1 – 6

C. β 1 – 6

D. α 1 – 4

16. Building blocks of nucleic acids are

A. N ucleotides

B. Histones

C. Nucleosides

D. Amino acids

17. Humans are unable to digest

A. starch

B. denatured proteins

C. cellulose

D. complex carbohydrates

18. The sugar which forms major component of nucleic acids is

 

A. maltose

B. mannose

C. galactose

D. ribose

19. Which of the following statements is true?

A. Sugar component of a nucleotide is ribose

B. T he bases in nucleotides are attached to a pentose sugar moiety by a glycosidic linkage

C. Sugar component of a nucleotide is deoxyribose

D. The sugar molecule of the nucleotide is in L-configuration

20. The glycosidic bond

A. in maltose is not hydrolyzed in lactose intolerant humans

B. joins glucose and fructose to form sucrose

C. in sucrose is hydrolyzed by bees

D. both (b) and (c)

21. Which of the following statements is true?

A. Sugar component of a nucleotide is deoxyribose

B. The sugar molecule of the nucleotide is in L-configuration

C. Sugar component of a nucleotide is ribose

D. The bases in nucleotides are attached to a pentose sugar moiety by a glycosidic linkage

22. The compound that consists of ribose linked by an N-glycosidic bond to N-9 of adenine is:

A. deoxyribonucleoside

B. a pyrimidine nucleotide

C. a purine nucleotide

D. adenosine

23. Which is a general property of  both nucleosides and  nucleotides?

A. Both contain a  nitrogenous  base that forms covalent H-bonds

B. B oth contain a pentose in the form of a furanose

C. Both contain a  hemiacetal or hemiketal bond

D. Both contain at least one  5’-phosphate group

 

24. Glycosidic  bond in sucrose is

A. α 1 – 4

B. β 1 – 2

C.   α 1 – 2

D.  β 1 – 4

25. The sugar molecule in a nucleotide is

A. Tetrose

B. Hexose

C. Pentose

D. Triose

26. Find out the example of amino sugar.

A. Fructose

B. Mannose

C. S ialic Acid

D. Sucrose

27. Cellulose can not be digested by

A. Plants

B. F ish & mammals

C. Herbivores

D. Fungi

28. Starch is broken down to form glucose units when hydrolyzed by

A. Alkaline medium

B. A cidic medium

C. Neutral medium

D. Salty medium

29. Starch is commonly formed and stored in

A. Animals

B. Plants

C. Fish

 D. Insects

30. Common test for starch presence is

A. Bendict test

B. I odine test

C. Biuret test

D. Bromine test

31. Presence of starch verifies that

A. Photosynthesis has not taken place

B. P hotosynthesis has taken place

C. It has nothing to do with photosynthesis

D. None of above

32. Nucleotides are

A. Purine bases

B. N itrogen bases + Pentose sugar

C. Nitrogen bases + Pentose sugar + Phosphate

D. None of above

33. Which of the following is not the precursor for the denovo purine biosynthesis?

A. Aspartic Acid

B. Glycine

C. Glutamine

D. A rginine

34. which of the following serves as the cofactor for the denovo synthesis of purine metabolism?

A. Thiamine

B. Biotine

C. F olate

D. Flavin

 

CHN 701(O) Unit 2 Conformational Analysis

1. Arrange the following conformers of butane in order of energy, lowest to highest

A. a nti < gauche < eclipsed < totally eclipsed

B. gauche<anti<  totally eclipsed<eclipsed

C. gauche<eclipsed<anti<  totally eclipsed

D. eclipsed< gauche< anti< totally eclipsed

2. The infinity of  intermediate conformations are called 

A. Gauche

B. S kew conformations

C. Eclipsed conformations

D. Staggered conformations

3. Which conformation of trans- 1 - isopropyl - 3 - methyl cyclohexane would be present in greatest amount at equilibrium?

A. The conformation with both groups equatorial

B. The conformation with both groups axial

C. The conformation with the methyl group equatorial and the isopropyl group axial

D. T he conformation with the methyl group axial and the isopropyl group equatorial

4. Gauche conformation is  less stable due to 

A. Hydrogen bonding

B. Torsional strain

C. V ander Waal’s repulsion

D. Covalent bonding

5. Which cyclo alkane has the least ring strain

A. Cyclo propane

B. C yclo hexane

C. Cyclo pentane

D. Cyclo butane

6. Which of the following is the highest energy conformation of cyclo hexane?

A. eclipsed

 B. h alf- chair

C. chair

D. boat

7. How many constitutional isomers are possible for the formula C₆H₁₄?

A. 3

B. 4

C. 5 

D. 2

8. Arrange the following trans 1,2 Di methyl Cyclohexane conformers in order of  its Stability is

A. aa > ee > ea

B. ee > aa > ea

C. e e > ea > aa

D. aa > ea > ee

9. In the most stable conformation of cis-1,4-dimethyl cyclohexane, the methyl groups are:

A. both equatorial

B. both axial

C. alternating between being both axial and both equatorial

D. o ne axial, one equatorial

10. Conformations are different arrangements of atoms that can be converted into one another by rotation about

A. S ingle bond

B. Covalent bond

C. Triple bond

D. Double bond

11. Point group of Bicyclo (2,2,2) Octane is

A. D ₃h

B. D₂d

C. C₃h

D. D₃d

 

12. The rotation about the (C₂– C₃) carbon-carbon bond of n-butane requires the energy of about

A. 30 kJ/mole

B. 100 kJ/mole

C. 3 kJ/mole

D. 50 kJ/mole

13. Which of the following is least stable?

A. Anti conformation

B. Gauche conformation

C. Staggered conformation

D. E clipsed conformation

14. 2-bromo cyclohexanone is more stable when

A. Br is at axial Position

B. Br is at equatorial Position

C. Both Position

D. None of above

15. In gauche conformations, the methyl  groups are_

A. 180⁰ apart

B. 360⁰ apart

C. 6 0⁰ apart

D. 90⁰ apart

16. which form is more stable in Cyclohexane -1,4 diol

A. Boat

B. twist

C. Half Chair

D. Chair

17. Trans - Cyclopropane 1,2 di carboxylic acid is

A. Meso compound

B. N one of the above

 C. Optically inactive

D. Optically active

18. Which of the following statements is a correct description of the most stable conformation of 1, 1, 3- tri methyl cyclohexane?

A. C-1 is a tertiary carbon and C-3 is a primary carbon

B. C-1 is a tertiary carbon and C-3 is a secondary carbon

C. C-1 is a quaternary carbon and C-3 is a secondary carbon

D. T he methyl group at C-3 is equatorial

19. How many stereo isomers are present in 2-Hydroxy Methyl 1-cyclopropane Carboxylic  acid

A. 8

B. 4 

C. 16

D. 2

20. Which of the following correctly lists the conformations of cyclo hexane in order of increasing energy?

A. chair < boat < twist <  half-chair

B. c hair < twist < boat < half-chair

C. chair < twist < half-chair <  boat

D. half-chair < boat < twist <  chair

21. Trans 1,2 di carboxylic acid is more stable than its Cis form Because of

A. T orsional angle 120⁰

B. Torsional  angle 60⁰

C. Torsional  angle 30⁰

D. Torsional  angle 90⁰

22. Which of the  statements below correctly describes the chair conformations of trans- 1, 4-  di methyl cyclohexane?

A. The two chair conformations are of equal energy

B. The higher energy chair conformation contains one axial methyl group and one equatorial Methyl group

 C. The lower energy chair conformation contains one axial methyl group and one equatorial Methyl group

D. T he higher energy chair conformation contains two axial methyl groups

23. The energy required to rotate n-butane molecules about the carbon-carbon bond is called

A. Potential energy

B. T orsional Energy

C. Rotational energy

D. Enantiomeric Energy

24. The most stable configuration of n-butane will be

A. Skew boat

B. Eclipsed

C. Gauche

D. Staggered anti

25. The dihedral angle between the hydrogen atoms of two methyl groups in staggered conformation of ethane is:

A. 120o

B. 180o

C. 90o

D. 60o

26. Which one of the following is the stable structure of cyclohexatriene?

A. Chair form

B. Boat form

C. Half chair form

D. Planar form

27. In butane which of the following forms has the lowest energy?

A. Gauche form

B. Eclipsed form

C. S taggered form

D. None of these

 

CHN 701(O) Unit-3 Steroids & Hormones

1. What are the steroid hormones made from?

A. C holesterol

B. Ergo sterol

C. Lanosterol

D. None of above

2. Steroids usually share which common structure feature?

A. Methyl group at position 8 and 9

B. A hydrocarbon functional group at position 17

C. A nitrogen containing functional group at position 3

D. Four fused six-membered rings.

3. steroids are 

A. S olid alcohol

B. Liquid alcohol

C. A & B

D. None of above

4. What is the molecular formula of ergosterol?

A. C 28H44O

B. C30H50O

C. C21H29O5

D. C21H30O2

5. Sources  of ergosterol

A. Plants

B. Animals

C. Yeast

D. A ll of above

6. On hydrogenation with  platinum ergosterol forms 

A. E rgostenol

B. Ergosterol acetate

C. Ergosterol nitrate

D. None of above

7. Molecular Formula  of lanosterol

A. C28H44O

B. C 30H50O

C. C21H29O5

D. C21H30O2

8. Molecular formula  of progesterone

A. C28H44O

 B. C30H50O

C. C21H29O5

D. C 21H30O2

9. Molecular formula  of cortisone

A. C28H44O

B. C30H50O

C.  C 21H29O5

D.  C21H30O2

10. Cortisone on oxidation with  HIO4 yields

A. 17-hydroxy acid

B. 15-hydroxy acid

C. 13-hydroxy acid

D. 19-hydroxy acid

11. How many double bonds are present in ergosterol?

A. One

B. Two

C. T hree

D. Four

12. How many active double bonds are present in lanosterol?

A. O ne

B. Two

C. Three

D. Zero

13. Oestrone on reduction  with LiAlH4 gives 

A. Oestrodiol

B. Oestrotriol

C. Oestrone hydride

D. None of above

14. Oestriol on reaction with KHSO4   gives 

A. Oestrodiol

B. O estrone

C. Oestrone hydride

D. None of above

15. Progesterone on reaction with NH2OH gives two  oxime  indicates that

A. T here are two kenotic groups are present

B. There are two aldehydes groups are present

C. There are two ester groups are  present

D. There are two ether groups are  present

 

16. Progesterone gives  haloform  test indicates that presence of 

A. -CO-

B. –CHO

C. - COCH3

D. -COOCH3

17. Progesterone  synthesized from 

A. D iosgenine

B. Cholesterol

C. A & B

D. None of above

18. Cortisone is example of which type of hormone?

A. A drenol cortical hormone

B. Mineralocorticoid

C. Androgens

D. None of above

19. Primary, secondary and ternary alcohol distinguish by which test?

A. L ucas test

B. Silver mirror test

C. Benedict test

D. None of above

20. Cortisone on oxidation  with HIO4 and CrO3 gives  respectively

A. 1 7-hydroxy acid, Adrenosterone

B. Adrenosterone,  17-hydroxy acid

C. Triketone, 17-hydroxy acid

D. 17-hydroxy acid, Androstane

21. Steroids have 

A. Sterol nucleus with two alkyl chain attached to the ring D of cholesterol

B. Sterol nucleus with two CH3 between C and D ring and A and B ring of cholesterol

C. Sterol nucleus without CH3 between C ring and D ring of cholesterol

D. S terol nucleus but lack the alkyl chain attached to the ring D of cholesterol

22. Which of the following regulates the female reproductive cycle?

A. P rogesterone

B. Testosterone

C. Estrogens

D. Glucocorticoids

23. Which is the first intermediate in cholesterol synthesis?

A. M evalonate

B. Isoprene

 C. Squalene

D. Ethylene

24. Which of the following is known as male hormone?

A. Progesterone

B. T estosterone

C. Estrogens

D. Glucocorticoids

25. how many keto groups are present in cortisone?

A. One

B. Two

C. Three

D. None